Methamphetamine research report: what is methamphetamine? Oct 2019. This results in a higher potential for widespread misuse for methamphetamine compared to amphetamine. Neurobiology and clinical manifestations of methamphetamine neurotoxicity. Methamphetamine also has longer-lasting and more severe adverse effects on the central nervous system than amphetamine. Methamphetamine use: a comprehensive review of molecular, preclinical and clinical findings. Panenka WJ, Procyshyn RM, Lecomte T, et al. Amphetamine and methamphetamine are both highly addictive stimulants, which affect the central nervous system in similar ways methamphetamine differs from amphetamine in that, at comparable doses, greater amounts of drug get into the brain, resulting in increased potency. Prescribed stimulants may be diverted into the illegal market, and methamphetamine is often manufactured illicitly. Pharmacologic mechanisms of crystal meth. Washington, DC: American Psychiatric Publishing 2022. Prescribed doses of amphetamine and methamphetamine are typically much lower than those taken in misuse. Diagnostic and statistical manual of mental disorders, 5th edition, text revision (DSM-5-TR). They have a number of therapeutic uses including for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adults, for narcolepsy, and occasionally as a short-term treatment for obesity. Amphetamine and methamphetamine are non-catecholamine sympathomimetic amines that may be taken by various routes including inhalation, intravenous, intramuscular, or transmucosal (oral/nasal).
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